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Common Drugs for LMS

 

Chemotherapy

(Cytotoxic – kills all fast growing healthy and cancerous cells in your body)

Adriamycin/doxorubicin
Aldoxorubicin
Doxil/doxorubicin liposomal
DTIC/decarbazine
Ellence/epirubicin
Gemzar/gembcitabene
Halaven/erubulin
Ifex/ifosfamide
Taxotere/docetaxol
Temodar/temozolomide
Yondelis/trabectedin (specifically approved for leiomyosarcoma)

 

Targeted

(Disrupts pathways to cancer cell growth)

Avastin/bevacizumab/ – angiogenesis inhibitor targets VEGF-A
Nexavar/sorafenib – tyrosine kinase inhibitor, angiogenesis inhibitor, VEGF inhibitor
Sutent/Sunitinib/SU11248 – tyrosine kinase inhibitor, VEGF & angiogenesis inhibitor
Votrient/pazopanib – votrient targets tyrosine kinases

 

Immunotherapy

(Helps your immune system to recognize and destroy cancer cells)
Keytruda/pembrolizumab – monoclonal antibody targeting PD1 receptor
Lartruvo/olaratumab – monoclonal antibody targeting PDGF receptor
Opdivo/nivolumab – monoclonal antibody targeting PD1 receptor / check point inhibitor
Yervoy/ipilimumab – monoclonal antibody targeting CTLA-4 receptor

 

Hormonal Blockade

(Effects tumor growth by blocking hormones and hormone receptors)

Arimidex/anastrozole – aromatase inhibitor
Aromasin/exemestane – aromatase inhibitor – irreversible
Evista/raloxifene – estrogen receptor modulator
Faslodex/fulvestrant – estrogen receptor modulator
Femara/letrozole – aromatase inhibitor
Lupron/leuprolide – shuts down ovary estrogen production temporarily
Megace/megastrol – progesterone analog
Nolvadex/tamoxifen –(not for uterine LMS) selective estrogen-receptor modulator

 

Supportive/Chemoprotective

(Agents added to protect healthy cells during cytotoxic chemo)

Mesna/mesnex – bladder chemoprotectant (ifosfomide and cyclophosphamide)
Dexrazoxane – cardio and vascular chemoprotectant (doxorubicin)
Coumadin/warfarin – anticoagulent
Decadron/dexamethasone – adrenal corticosteriod supplement
Neupogen/filgrastim – white cell production booster
Neulasta/pegfilgrastim – white cell production booster
Leukine/sargramostim – white cell production booster
Zometa/zoledronic acid//reclast – bone and serum calcium related
Zoladex/goserelin – ovarian estrogen production inhibitor